| Thrombotic microangiopathies: multimers, metalloprotease, and beyond. | |
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MedLine Citation:
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PMID: 20443921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathophysiology of various types of thrombotic microangiopathies is coming progressively into focus. Therapeutic advances are likely to follow at a quickening pace. This discussion focuses on thrombotic thrombocytopenic purpura (TTP), the hemolytic-uremic syndrome (HUS), thrombotic microangiopathies associated with transplantation-immunosuppression or anti-angiogenesis therapy, and the preeclampsia/hemolysis-elevated liver enzymes and low platelets syndrome (HELLP). |
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Authors:
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Joel Moake |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and translational science Volume: 2 ISSN: 1752-8062 ISO Abbreviation: Clin Transl Sci Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474067 Medline TA: Clin Transl Sci Country: United States |
Other Details:
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Languages: eng Pagination: 366-73 Citation Subset: IM |
Affiliation:
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Rice University, Houston, Texas, USA. jmoake@rice.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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metabolism Angiogenesis Inhibitors / pharmacology Antineoplastic Agents / pharmacology Hemolytic-Uremic Syndrome / diagnosis, genetics Humans Immunosuppressive Agents / pharmacology Metalloproteases / metabolism* Models, Biological Platelet Adhesiveness Protein Structure, Tertiary Purpura, Thrombotic Thrombocytopenic / diagnosis, genetics Thrombotic Microangiopathies / diagnosis*, enzymology*, physiopathology von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antineoplastic Agents; 0/Immunosuppressive Agents; 0/von Willebrand Factor; EC 3.4.-/Metalloproteases; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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