| Thrombotic arteriopathy and anticoagulation in pulmonary hypertension. | |
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MedLine Citation:
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PMID: 16899857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of thrombotic arteriopathy in the pathophysiology of idiopathic pulmonary arterial hypertension (IPAH) and the use of anticoagulants in the treatment of IPAH are currently controversial issues. This article reviews the evidence for a role of vascular thrombosis in the pathophysiology of IPAH. There is sufficient biological rationale to support the notion that thrombotic arteriopathy is an important pathophysiologic feature of pulmonary arterial hypertension (PAH) and that its progression materially contributes to disease progression. To date, the data from observational studies suggest that anticoagulation with warfarin is an effective intervention in patients with IPAH. Its efficacy in other causes of PAH remains speculative. |
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Authors:
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Sindhu R Johnson; John T Granton; Sanjay Mehta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Chest Volume: 130 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-10 Completed Date: 2006-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 545-52 Citation Subset: AIM; IM |
Affiliation:
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Division of Rheumatology, University Health Network, University of Toronto, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Disease Progression Humans Hypertension, Pulmonary / drug therapy, etiology* Pulmonary Artery* Thromboembolism / complications*, drug therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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