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Thrombotic Thrombocytopenic Purpura: A Hematological Emergency.
MedLine Citation:
PMID:  22445678     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Thrombotic thrombocytopenic purpura is a hematological emergency and diagnostic challenge. The critical determinant of outcome is timely diagnosis and treatment. OBJECTIVES: Describe the pathophysiology, presentation, diagnosis, and treatment of thrombotic thrombocytopenic purpura. DISCUSSION: Thrombotic thrombocytopenic purpura has a varied presentation and a tendency to mimic several disorders. However, it may be at least provisionally diagnosed in the patient with thrombocytopenia and microangiopathic hemolytic anemia without alternate cause. The mainstay of treatment is immediate plasma exchange to be repeated until platelet count is stabilized. Adjuvant therapies include corticosteroids, rituximab, and cyclosporine. CONCLUSION: It is essential for the emergency physician to be aware of thrombotic thrombocytopenic purpura's range of presentations, diagnostic criteria, and treatment.
Authors:
Chad S Kessler; Bilal A Khan; Katie Lai-Miller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  -     ISSN:  0736-4679     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Department of Emergency Medicine, Jesse Brown VA Hospital, Chicago, Illinois; Department of Internal Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois; Department of Emergency Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois; Combined Internal Medicine/Emergency Medicine Residency, University of Illinois at Chicago College of Medicine, Chicago, Illinois.
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