Document Detail

Thrombotest mixing experiments in congenital coagulation disorders of the prothrombin complex and in coumarin treated patients. An additional evidence against the presence of an inhibitor in the latter.
MedLine Citation:
PMID:  72033     Owner:  NLM     Status:  MEDLINE    
Thrombotest clotting times of mixtures of coumarin plasmas and normal plasma yielded a patterm similar to that observed in mixtures of plasma with congenital coagulation disorders and normal plasma. The presence of 10 or 20% of test plasma in the mixture failed to affect the clotting times which resulted in normal limits. The only exception to this rule was the hemophilia BM plasma. In this case even the presence of 10-20% of patient plasma in the mixture caused a prolongation of the clotting time. This indicates that no inhibitor is present in coumarin plasmas and in the plasma of congenital coagulation disorders of the prothrombin complex save for hemophilia BM plasma which does contain an inhibitor.
A Girolami; O Patrassi; G Cella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia haematologica (Leipzig, Germany : 1928)     Volume:  104     ISSN:  0323-4347     ISO Abbreviation:  Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch.     Publication Date:  1977  
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374615     Medline TA:  Folia Haematol Int Mag Klin Morphol Blutforsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  463-70     Citation Subset:  IM    
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MeSH Terms
Acenocoumarol / pharmacology*
Blood Coagulation*
Blood Coagulation Disorders / pathology*
Blood Coagulation Tests / methods
Hemophilia B / pathology
Warfarin / pharmacology
Reg. No./Substance:
152-72-7/Acenocoumarol; 81-81-2/Warfarin; 9001-26-7/Prothrombin; 9035-58-9/Thromboplastin

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