| Thrombosis in myelofibrosis: prior thrombosis is the only predictive factor and most venous events are provoked. | |
| | |
MedLine Citation:
|
PMID: 20884719 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
In a retrospective analysis of 205 patients (median age 62 years) with primary myelofibrosis and known JAK2V617F mutational status, 13.2% experienced a vaso-occlusive event at or prior to their diagnosis. After a median follow up of 31 months, post-diagnosis thrombosis occurred in 22 patients (10.7%), including 9 (4.4%) and 16 (7.8%) patients with a total of 9 arterial and 24 venous events, respectively. The majority (71%) of the venous events were temporally associated with other exogenous risk factors for thrombosis such as surgery, line placement or hormonal therapy. On multivariable analysis that included age, JAK2V617F mutation status and leukocyte count as covariates, history of thrombosis was the only predictive variable in general (P=0.04) or when arterial (P=0.007) and venous (P=0.02) thromboses were analyzed separately. The current study demonstrates a higher prevalence of venous, as opposed to arterial, events in PMF, post-diagnosis, and clarifies their nature as being mostly provoked. |
| | |
Authors:
|
Michelle Ann Elliott; Animesh Pardanani; Terra L Lasho; Susan M Schwager; Ayalew Tefferi |
Related Documents
:
|
21042459 - Mobile right heart thrombus with pulmonary embolism in a patient with polycythemia rubr... 10457409 - Lipoprotein(a) concentration is not associated with venous thromboembolism in a case co... 20974769 - Internal jugular vein thrombosis: outcome and risk factors. 3971539 - Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction a... 18030499 - Arterial thrombosis associated with factor v leiden and methylenetetrahydrofolate reduc... 8902459 - Symptomatic inferior vena cava filter thrombosis: clinical study of 30 consecutive cases. 12736039 - Liposarcoma presenting as an intraluminal ureteral mass. 3980569 - Screening for the potential pulmonary embolism victim. 20842489 - Treatment of carotid cavernous fistulas. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Haematologica Volume: 95 ISSN: 1592-8721 ISO Abbreviation: Haematologica Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417435 Medline TA: Haematologica Country: Italy |
Other Details:
|
Languages: eng Pagination: 1788-91 Citation Subset: IM |
Affiliation:
|
Division of Hematology/Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. elliott.michelle@mayo.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CD30+ lymphoproliferative disorders.
Next Document: Bone changes in the mandible following botulinum neurotoxin injections.