Document Detail


Thrombosis in children with cardiac pathology: frequency of factor V Leiden and prothrombin G20210A mutations.
MedLine Citation:
PMID:  12522659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study analyzed 28 thrombotic children with various cardiac disorders. They comprise 17% of a total of 168 patients with thrombosis from a single center. Among the 28 patients, 21 had congenital heart disease and 7 were diagnosed with cardiomyopathy. The patients with thrombosis were evaluated for congenital and acquired thrombotic risk factors. In addition to cardiac disorders, two, three, or more risk factors were present in 61% of the children with thrombosis. Two common mutations, namely factor V Leiden and prothrombin G20210A mutations, were found in 6 patients (22%). Nine patients (32%) died of infection, congenital heart disease, cardiomyopathy, thrombosis, operation, or a combination of these; two patients required surgical intervention. Following cardiac angiography, due to necrosis, amputation of the right index finger and right lower extremity was performed on 1 patient. The second patient's index fingers had to be amputated and resection of the bowel was performed following the operation on coarctation of the aorta. This study indicates that congenital heart disease and cardiomyopathy are two common cardiac disorders that may lead to the development of thrombosis. The majority of thrombosis develops within the heart and/or its great vessels. The second predominant site for thromboembolic symptoms is in the brain, including sinovenous thrombosis.
Authors:
A Gurgey; E Ozyurek; F Gümrük; A Celiker; S Ozkutlu; S Ozer; A Bilgiç
Related Documents :
14608129 - Use of lepirudin during percutaneous vascular interventions in patients with heparin-in...
15544909 - Impact of short-term hemodialysis catheters on the central veins: a catheter venographi...
9858229 - No treatment for low-risk thrombocythaemia: results from a prospective study.
10102459 - Clinical prediction of deep vein thrombosis in patients with leg symptoms.
16095119 - Livedo reticularis is a marker for predicting multi-system thrombosis in antiphospholip...
12540959 - Ruling out clinically suspected pulmonary embolism by assessment of clinical probabilit...
2219459 - Complement activation in pulmonary tuberculosis.
20428649 - Prevalence of human papillomavirus (hpv) and hpv-16 genotyping by real-time pcr in pati...
10460189 - The value of synovial fluid analysis in the assessment of knee joint destruction in art...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-01-15
Journal Detail:
Title:  Pediatric cardiology     Volume:  24     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-06-05     Completed Date:  2003-11-12     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Pediatric Hematology Unit, Hacettepe University, Faculty of Medicine, Ihsan Dogramac? Children's Hospital, 06100, Ankara, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Cardiomyopathies / complications,  genetics*
Child
Child, Preschool
Factor V / genetics*
Female
Heart Defects, Congenital / complications,  genetics*
Humans
Infant
Infant, Newborn
Male
Mutation
Prothrombin / genetics*
Risk Factors
Thrombosis / complications,  genetics*
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Streamlining fluid pathways lessens flow energy dissipation: relevance to atriocavopulmonary connect...
Next Document:  Bone marker alterations in patients with type 1 Gaucher disease.