Document Detail

Thrombosis and fibrinolysis in acute myocardial infarction.
MedLine Citation:
PMID:  8198233     Owner:  NLM     Status:  MEDLINE    
The development of coronary thrombosis in response to rupture of atherosclerotic plaques is the primary determinant of the evolution of stable atherosclerotic coronary disease to unstable ischemic syndromes and acute myocardial infarction. Activation of the tissue factor pathway of coagulation and adhesion of platelets are critical events in the initiation of thrombosis. However, subsequently, other factors may determine the extent of thrombosis by modulating the intensity of procoagulant and fibrinolytic activity. Marked procoagulant activity, attenuation of physiologic fibrinolytic activity, or both appear to be risk factors for myocardial infarction. The results of recent studies have provided considerable insight into potential mechanisms for thrombosis in response to rupture of atherosclerotic plaque and have identified potential novel antithrombotic interventions to inhibit the progression of coronary thrombosis.
P R Eisenberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  18     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-30     Completed Date:  1994-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Blood Coagulation Factors / physiology
Coronary Artery Disease / blood*
Coronary Thrombosis / blood*
Fibrinolysis / physiology*
Myocardial Infarction / blood*
Platelet Activation / physiology
Grant Support
Reg. No./Substance:
0/Blood Coagulation Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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