| Thrombosis and fibrinolysis in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 8198233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of coronary thrombosis in response to rupture of atherosclerotic plaques is the primary determinant of the evolution of stable atherosclerotic coronary disease to unstable ischemic syndromes and acute myocardial infarction. Activation of the tissue factor pathway of coagulation and adhesion of platelets are critical events in the initiation of thrombosis. However, subsequently, other factors may determine the extent of thrombosis by modulating the intensity of procoagulant and fibrinolytic activity. Marked procoagulant activity, attenuation of physiologic fibrinolytic activity, or both appear to be risk factors for myocardial infarction. The results of recent studies have provided considerable insight into potential mechanisms for thrombosis in response to rupture of atherosclerotic plaque and have identified potential novel antithrombotic interventions to inhibit the progression of coronary thrombosis. |
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Authors:
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P R Eisenberg |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 18 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-06-30 Completed Date: 1994-06-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Factors / physiology Coronary Artery Disease / blood* Coronary Thrombosis / blood* Fibrinolysis / physiology* Humans Myocardial Infarction / blood* Platelet Activation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-17646/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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