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Thromboprophylaxis implementation during pregnancy in women with recurrent foetal losses and thrombophilia.
MedLine Citation:
PMID:  22097113     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Recurrent foetal loss is a significant clinical problem, occurring in 1-5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed in 50-65% of women with history of unexplained foetal loss. The low molecular weight heparin was applied in 24 women with inherited thrombophilia and previous recurrent foetal loss and in 6 women with primary antiphospholipid syndrome throughout their following pregnancies. The dose of low molecular weight heparin for the majority of women was 35-75 u/kg. Women with primary antiphospholipid syndrome received both low molecular weight heparin and aspirin 50-100 mg daily. Implementation of thromboprophylaxis resulted in successful pregnancy outcome in 29 out of38 pregnancies, which represents a significant improvement of pregnancy outcome in comparison to previous 81 pregnancy losses. The number of treated pregnancies in our study is small, but the rate of successful pregnancy outcomes is high (76%), indicating that low molecular weight heparin may be a promising approach to women with thrombophilia and recurrent foetal loss.
Authors:
Gorana Mitić; Aleksandra Novakov Mikić; Ljubica Povazan; Anita Mitreski; Vesna Kopitović; Tihomir Vejnović
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicinski pregled     Volume:  64     ISSN:  0025-8105     ISO Abbreviation:  Med. Pregl.     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-11-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985249R     Medline TA:  Med Pregl     Country:  Serbia    
Other Details:
Languages:  eng     Pagination:  471-5     Citation Subset:  IM    
Affiliation:
Clinical Centre of Vojvodina, Novi Sad, Thrombosis and Haemostasis Unit, Institute of Laboratory Diagnostics. miticgns@yahoo.com
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