| Thromboprophylactic effect of ticlopidine in arteriovenous fistulas for haemodialysis. | |
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MedLine Citation:
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PMID: 3895411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When constructing arteriovenous fistulas for haemodialysis in chronic renal failure patients, one of the main problems is still their clotting tendency. Ticlopidine is an effective inhibitor of platelet aggregation. In this randomized double-blind study placebo or ticlopidine 250 mg twice daily was given to chronic uremic patients up to 4 weeks after construction of an arteriovenous fistula. 42 patients were recruited and 36 completed the trial. The fistula clotted in 8 patients on placebo and in 2 patients on ticlopidine. The difference is significant. This effect was achieved without an increased frequency of side effects compared with placebo. It is concluded that ticlopidine has a function as a thromboprophylactic drug in chronic uremic patients. |
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Authors:
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K C Gröntoft; H Mulec; A Gutierrez; R Olander |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: 19 ISSN: 0036-5599 ISO Abbreviation: Scand. J. Urol. Nephrol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-09-16 Completed Date: 1985-09-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 55-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticoagulants / therapeutic use* Arteriovenous Shunt, Surgical* Clinical Trials as Topic Double-Blind Method Female Graft Occlusion, Vascular / prevention & control Humans Male Middle Aged Postoperative Complications Renal Dialysis* Thiophenes / therapeutic use* Thrombosis / prevention & control* Ticlopidine |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Thiophenes; 55142-85-3/Ticlopidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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