Document Detail


Thrombopoietin level in patients with chronic liver diseases.
MedLine Citation:
PMID:  18753991     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombocytopenia and oxidative stress are the most frequent problems in patients with chronic liver diseases as viral cirrhosis and schistosomiasis. So, this study aimed to evaluate the role of thrombopoietin (TPO) on the occurrence of thrombocytopenia and in differentiation between these diseases. It also aimed to investigate the relation between TPO, oxidative stress and antioxidant status in these two types of chronic liver disease. So, We measured serum TPO level, lipid peroxide (MDA) and serum total antioxidant activity (TAO) in 40 patients with cirrhosis caused by hepatitis C virus and 37 patients with schistosomiasis from The Specialized Medical Hospital, Mansoura University. Results: Both serum TPO level and serum TAO activity were significantly lower (p < 0.05) in thrombocytopenic patients with viral cirrhosis when compared to both non thrombocytopenic and control groups. In contrast, TPO level was within the normal range in the patients with scistosomiasis either thrombocytopenic or not. while serum TAO activity was significantly lower (p < 0.05) in both thrombocytopenic and non thrombocytopenic patients with schistosomiasis in comparison to control subjects with no significant difference between these two subgroups. Serum MDA concentration was increased significantly (p < 0.05) in all diseased groups when compared to controls with significant increase in thrombocytopenic patients as compared to non thrombocytopenic. Conclusion: TPO hypoproduction played a role in the pathogenesis and treatment of viral cirrhosis associated with thrombocytopenia. Also, total antioxidant activity and MDA are useful markers for monitoring patients with these chronic liver diseases.
Authors:
Laila A Eissa; Lamees S Gad; Ahmed M Rabie; Amal M El-Gayar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  7     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2008 Jul-Sep
Date Detail:
Created Date:  2008-08-28     Completed Date:  2009-01-15     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  235-44     Citation Subset:  IM    
Affiliation:
Dept. of Biochemistry - Faculty of Pharmacy - Mansoura, University 35516, Egypt. lailaeissa2002@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antioxidants / metabolism*
Biological Markers / blood
Female
Hepatitis C, Chronic / blood,  complications
Humans
Liver Cirrhosis / blood*,  complications,  virology
Male
Malondialdehyde / blood
Middle Aged
Oxidative Stress*
Schistosomiasis / blood*,  complications
Thrombocytopenia / blood,  etiology*
Thrombopoietin / blood*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 542-78-9/Malondialdehyde; 9014-42-0/Thrombopoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Model for end stage of liver disease (MELD) is better than the Child-Pugh score for predicting in-ho...
Next Document:  Liver overload in Brazilian triathletes after half-ironman competition is related muscle fatigue.