Document Detail


Thrombopoietin improved ventricular function and regulated remodeling genes in a rat model of myocardial infarction.
MedLine Citation:
PMID:  22770769     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Thrombopoietin (TPO) protects against heart damages by doxorubicin-induced cardiomyopathy in animal models. We aimed to investigate the therapeutic efficacy of TPO for treatment of myocardial infarction (MI) in a rat model and explored the mechanisms in terms of the genome-wide transcriptional profile, TPO downstream protein signals, and bone marrow endothelial progenitor cells (EPCs). METHODS: Sprague-Dawley rats were divided into 3 groups: Sham-operated, MI (permanent ligation of the left coronary artery) and MI+TPO. Three doses of TPO were administered weekly for 2weeks, and outcomes were assessed at 4 or 8weeks post-injury. RESULTS AND CONCLUSIONS: TPO treatment significantly improved left ventricular function, hemodynamic parameters, myocardium morphology, neovascularization and infarct size. MI damage upregulated a large cohort of gene expressions in the infarct border zone, including those functioned in cytoskeleton organization, vascular and matrix remodeling, muscle development, cell cycling and ion transport. TPO treatment significantly reversed these modulations. While phosphorylation of janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) was modified in MI animals, TPO treatment regulated phosphorylation of STAT3 and extracellular signal-regulated kinases (ERK), and bone morphogenetic protein 1 (BMP1) protein level. TPO also increased EPC colonies in the bone marrow of MI animals. Our data showed that TPO alleviated damages of heart tissues from MI insults, possibly mediated by multi-factorial mechanisms including suppression of over-reacted ventricular remodeling, regulation of TPO downstream signals and mobilization of endothelial progenitor cells. TPO could be developed for treatment of cardiac damages.
Authors:
Kathy Yuen Yee Chan; Ligang Zhou; Ping Xiang; Karen Li; Pak Cheung Ng; Chi Chiu Wang; Ming Li; Nga Hin Pong; Liu Tu; Haiyan Deng; Carrie Ka Lai Kong; Rita Yn Tz Sung
Related Documents :
1550019 - Survival after implantation of the cardioverter defibrillator.
11520449 - Arrhythmogenic right ventricular cardiomyopathy: current diagnostic and management stra...
2058559 - Clinical and angiographic observations on resuscitated victims of exercise-related sudd...
3336399 - Right ventricular cardiomyopathy and sudden death in young people.
22043289 - Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 ...
21925839 - Cardioprotective effects of low-dose combination therapy with a statin and an angiotens...
2073499 - Use of replacement estrogens and the risk of myocardial infarction.
6603749 - Serial sonography of posthemorrhagic ventricular dilatation and porencephaly after intr...
1449439 - Mitral valve palpitations.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Calibration of the GENEA accelerometer for assessment of physical activity intensity in children.
Next Document:  Marine and freshwater concentration ratios (CR(wo-water)): review of Japanese data.