Document Detail


Thrombopoietic cytokines and platelet count in multiple myeloma.
MedLine Citation:
PMID:  19891528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines like interleukin (IL)-6 and IL-1beta are both implicated in multiple myeloma (MM) pathogenesis and megakaryopoiesis. The dynamic interaction between thrombopoiesis and thrombopoietic cytokines in MM may affect platelet (PLT) counts. Sixty-eight patients with MM (30 female, 38 male; median age 58 (40-79), 38 newly diagnosed, 15 in plateau, and 15 relapse and/or refractory patients) and 21 controls were included in the study. Plasma levels of thrombopoietin (TPO), IL-1beta, IL-11 and IL-6 were measured by ELISA. PLT counts were not different between the control group and MM patients with various disease stages and activity. IL-6 and TPO levels were higher in MM patients than healthy subjects (p < 0.001). PLT counts were inversely correlated with TPO (r = -0.566; p < 0.001) and positively correlated with IL-6 (r = 0.263; p = 0.04) levels in MM patients. TPO and IL-6 levels were significantly correlated (r = 0.305; p < 0.001). Disease activity has no effect on plasma cytokine levels. TPO levels were higher in stage III than stage I (p = 0.05) and stage II (p = 0.03) patients in newly diagnosed MM. High TPO levels induced by IL-6 may sustain normal PLT counts despite bone marrow infiltration by plasma cells and decreased PLT half-life.
Authors:
Zübeyde Nur Ozkurt; Münci Yağci; Gülsan Türköz Sucak; Serafettin Kirazli; Rauf Haznedar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Platelets     Volume:  21     ISSN:  1369-1635     ISO Abbreviation:  Platelets     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-05     Revised Date:  2012-09-26    
Medline Journal Info:
Nlm Unique ID:  9208117     Medline TA:  Platelets     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Affiliation:
Gazi University, Faculty of Medicine, Department of Hematology, Beşevler, Ankara, Turkey. znozkurt@gazi.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cytokines / blood*
Female
Humans
Interleukin-11 / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Male
Megakaryocytes
Middle Aged
Multiple Myeloma / blood*,  physiopathology
Platelet Count*
Thrombopoiesis / physiology*
Thrombopoietin / blood
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-11; 0/Interleukin-1beta; 0/Interleukin-6; 9014-42-0/Thrombopoietin

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