Document Detail

Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients.
MedLine Citation:
PMID:  20162297     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Non-arteritic anterior ischemic optic neuropathy (N-AION) is caused by acute ischemic infarction of the optic nerve head, supplied by the posterior ciliary arteries. Thrombophilia is the tendency/predisposition to vascular thromboses of arteries and veins, and the existence of thrombophilic risk factors leads to blood hypercoagulability and potentially increased risk for thromboses. OBJECTIVES: To investigate whether there is an association between N-AION and a wide spectrum of thrombophilic risk factors. PATIENTS AND METHODS: Seventy-seven consecutive cases of confirmed N-AION and 60 age- and sex-matched consecutive controls constituted the study group. Fibrinogen levels, deficiency of proteins C, S, ATIII, lupus anticoagulant, activated protein C resistance, factor V Leiden, factor V H1299R, factor II G20210A, MTHFR C677T, MTHFR A1298C, GPIIIa A1/A2, and ACE I/D polymorphisms were analysed. RESULTS: Statistical analysis of the plasma proteins in our study demonstrated that the only significant difference was the one concerning protein S levels. In particular, the mean value for N-AION patients was 78.8% +/- 21.2, and for the control group the mean value was 88% +/- 21.2 (p = 0.013). Despite the above-mentioned result, there was not any statistical difference between the two subgroups regarding actual protein S deficiency, as 9/77 (11.7%) patients and 4/60 (6.7%) controls had protein S levels below 60% (p = 0.32). In our study sample, homozygosity for MTHFR C677T polymorphism in the study group as a whole, and the presence of at least one A2 allele of GPIIIa in the subgroup of male patients as compared to healthy male controls, proved to be the most significant thrombophilic risk factors, with odds ratios of 16.78 (95% C.I 0.96-294.42, p = 0.054) and 4.6 (95% C.I 1.52-13.88, p = 0.007) respectively. CONCLUSION: Screening for these polymorphisms would probably constitute a valuable procedure in N-AION patients, as they may have an important contribution to the pathogenesis of the disease.
Taxiarchis Felekis; Nikolaos I Kolaitis; Georgios Kitsos; Georgios Vartholomatos; Konstantinos L Bourantas; Ioannis Asproudis
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Publication Detail:
Type:  Journal Article     Date:  2010-02-17
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  248     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  877-84     Citation Subset:  IM    
University Eye Clinic of Ioannina, Kosti Palama 1, Anatoli, Ioannina, 45500, Greece.
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MeSH Terms
Aged, 80 and over
Atherosclerosis / genetics,  metabolism
Blood Proteins / genetics,  metabolism
Hyperlipidemias / genetics,  metabolism
Hypertension / genetics
Middle Aged
Optic Neuropathy, Ischemic / etiology*,  genetics,  metabolism
Oxidoreductases / genetics,  metabolism
Polymorphism, Genetic
Prospective Studies
Risk Factors
Thrombophilia / epidemiology*,  genetics,  metabolism
Reg. No./Substance:
0/Blood Proteins; EC 1.-/Oxidoreductases

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