Document Detail

Thrombophilic polymorphisms in Israel.
MedLine Citation:
PMID:  18583164     Owner:  NLM     Status:  MEDLINE    
Three thrombophilic polymorphisms, FV G1691A, FII G20210A and MTHFR C677T were investigated in Israeli populations by FRET, (fluorescence resonance energy transfer) real-time PCR. We observe extensive variability in the frequencies of each of the polymorphisms, as has been observed in the study of other polymorphisms in these populations. Very high allele frequencies for FV G1691A (the highest 0.087 in Turkish and Greek Jews) and FII G20210A (the highest 0.061 in Georgian Jews) in some of the Israeli populations justify a clinical investigation to assess their risk for venous thrombosis. Principal Coordinates Analysis demonstrates that the Jewish populations are interspersed among the non-Jewish populations. The resemblance of some Jewish populations to certain non-Jewish populations coincides with findings based on classical markers.
Avshalom Zoossmann-Diskin; Ephraim Gazit; Leah Peleg; Mordechai Shohat; David Turner
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Publication Detail:
Type:  Journal Article     Date:  2008-06-25
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  41     ISSN:  1096-0961     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-11-17     Revised Date:  2008-12-30    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Department of Haematology and Genetic Pathology, School of Medicine, Flinders University, Adelaide, Australia.
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MeSH Terms
Factor V / genetics*
Fluorescence Resonance Energy Transfer
Genetics, Population
Jews / genetics*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Prothrombin / genetics*
Thrombophilia / ethnology,  genetics*
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC Reductase (NADPH2)

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