| Thrombophilic polymorphisms in Israel. | |
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MedLine Citation:
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PMID: 18583164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three thrombophilic polymorphisms, FV G1691A, FII G20210A and MTHFR C677T were investigated in Israeli populations by FRET, (fluorescence resonance energy transfer) real-time PCR. We observe extensive variability in the frequencies of each of the polymorphisms, as has been observed in the study of other polymorphisms in these populations. Very high allele frequencies for FV G1691A (the highest 0.087 in Turkish and Greek Jews) and FII G20210A (the highest 0.061 in Georgian Jews) in some of the Israeli populations justify a clinical investigation to assess their risk for venous thrombosis. Principal Coordinates Analysis demonstrates that the Jewish populations are interspersed among the non-Jewish populations. The resemblance of some Jewish populations to certain non-Jewish populations coincides with findings based on classical markers. |
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Authors:
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Avshalom Zoossmann-Diskin; Ephraim Gazit; Leah Peleg; Mordechai Shohat; David Turner |
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Publication Detail:
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Type: Journal Article Date: 2008-06-25 |
Journal Detail:
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Title: Blood cells, molecules & diseases Volume: 41 ISSN: 1096-0961 ISO Abbreviation: Blood Cells Mol. Dis. Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2008-08-12 Completed Date: 2008-11-17 Revised Date: 2008-12-30 |
Medline Journal Info:
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Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 230-3 Citation Subset: IM |
Affiliation:
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Department of Haematology and Genetic Pathology, School of Medicine, Flinders University, Adelaide, Australia. avshalom.zoossmann-diskin@flinders.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Factor V
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genetics* Fluorescence Resonance Energy Transfer Genetics, Population Humans Israel Jews / genetics* Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Polymerase Chain Reaction Polymorphism, Single Nucleotide / genetics* Prothrombin / genetics* Thrombophilia / ethnology, genetics* |
| Chemical | |
Reg. No./Substance:
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0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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