Document Detail


Thrombophilic polymorphisms in Israel.
MedLine Citation:
PMID:  18583164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three thrombophilic polymorphisms, FV G1691A, FII G20210A and MTHFR C677T were investigated in Israeli populations by FRET, (fluorescence resonance energy transfer) real-time PCR. We observe extensive variability in the frequencies of each of the polymorphisms, as has been observed in the study of other polymorphisms in these populations. Very high allele frequencies for FV G1691A (the highest 0.087 in Turkish and Greek Jews) and FII G20210A (the highest 0.061 in Georgian Jews) in some of the Israeli populations justify a clinical investigation to assess their risk for venous thrombosis. Principal Coordinates Analysis demonstrates that the Jewish populations are interspersed among the non-Jewish populations. The resemblance of some Jewish populations to certain non-Jewish populations coincides with findings based on classical markers.
Authors:
Avshalom Zoossmann-Diskin; Ephraim Gazit; Leah Peleg; Mordechai Shohat; David Turner
Related Documents :
15720634 - Is variation in susceptibility to phytophthora ramorum correlated with population genet...
23464394 - Identification of genetic and non-genetic risk factors for nasopharyngeal carcinoma in ...
15711824 - Phenotypic plasticity in carlina vulgaris: effects of geographical origin, population s...
24689944 - Challenges and prospects in genome-wide quantitative trait loci mapping of standing gen...
15050514 - Searching for genetic influences on normal cognitive ageing.
1496994 - High frequency of mutations in exon 10 of the porphobilinogen deaminase gene in patient...
Publication Detail:
Type:  Journal Article     Date:  2008-06-25
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  41     ISSN:  1096-0961     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-08-12     Completed Date:  2008-11-17     Revised Date:  2008-12-30    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Affiliation:
Department of Haematology and Genetic Pathology, School of Medicine, Flinders University, Adelaide, Australia. avshalom.zoossmann-diskin@flinders.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Factor V / genetics*
Fluorescence Resonance Energy Transfer
Genetics, Population
Humans
Israel
Jews / genetics*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Prothrombin / genetics*
Thrombophilia / ethnology,  genetics*
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Growth of infant faecal bifidobacteria and clostridia on prebiotic oligosaccharides in in vitro cond...
Next Document:  The detection of Chlamydophila psittaci genotype C infection in dogs.