Document Detail


Thrombophilia-related genetic variations in patients with pulmonary embolism in the main teaching hospital in Jordan.
MedLine Citation:
PMID:  19618008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the frequency of Factor V Leiden (FVL), prothrombin gene mutation G20210A and methylenetetrahydrofolate reductase C677T in patients with acute pulmonary embolism (PE); and to investigate whether these factors are more frequent in patients who have no obvious risk factors for venous thrombo-embolism compared to those with obvious risk factors. METHODS: A case-control study conducted at Jordan University Hospital, Amman, Jordan during the period 2005-2007. Compared 92 patients with acute PE to 99 normal subjects. All subjects were investigated for the 3 genetically related thrombophilic factors. RESULTS: The frequency of these factors in patients were 22/92 (23.9%) FVL, 3/92 (3.3%) Factor II (FII) and 48/92 (52.2%) methylenetetrahydrofolate reductase (MTHFR). In the control group, FVL was 12/99 (12.1%), FII 0/99 (0%), and 53/99 (53.5%) MTHFR. There was a statistically significant difference between patients and controls for FVL (p=0.03), but no statistical significance for FII (p=0.10) and MTHFR (p=0.85). In patients with no obvious risk factors, the frequency of these factors were 8/29 (27.6%) FVL, 2/29 (6.9%) FII, and 14/29 (48.3%) for MTHFR compared to patients with obvious risk factors 14/63 (22.2%) for FVL, 1/63 (1.6%) FII, and 33/63 (52.3%) MTHFR. CONCLUSION: The FVL is statistically more frequent in patients with PE compared to the control group, and the frequency of FVL, FII, and MTHFR is not significantly higher in patients with acute PE who have no obvious risk factors compared to those with obvious risk factors.
Authors:
Nathir M Obeidat; Abdallah Awidi; Naef A Sulaiman; Ilham B Abu-Khader
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  30     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  921-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Critical Care and Sleep Medicine, Jordan University Hospital, Amman 11942, Jordan. nathirmo@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Factor V / genetics
Female
Genetic Variation
Hospitals, Teaching
Humans
Jordan
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Middle Aged
Mutation
Polymorphism, Restriction Fragment Length
Prothrombin / genetics
Pulmonary Embolism / genetics*
Risk Factors
Thrombophilia / genetics*
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

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