Document Detail

Thrombophilia and ovarian hyperstimulation syndrome: a case report.
MedLine Citation:
PMID:  21857739     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ovarian Hyperstimulation syndrome (OHSS) is one of the most serious complications of controlled ovarian hyperstimulation. Recent prospective data revealed possible increased prevalence of thrombophilia markers in women who develop severe ovarian hyperstimulation syndrome (OHSS).
CASE: A 26-year-old nulliparous woman underwent ovarian stimulation for in vitro fertilization with recombinant follicle stimulating hormone and developed severe OHSS. She was screened for hereditary and inherited thrombophilia markers and was found to be homozygous for MTHFR mutation and had decreased antithrombin levels.
CONCLUSION: This case adds to the limited information that there may be an association between women who develop severe ovarian hyperstimulation syndrome and an increased prevalence of underlying thrombophilia markers. If further research demonstrates a cost effective strategy, screening for those markers may identify women who are at a higher risk for development of severe ovarian hyperstimulation syndrome.
Gary Levy; Richard S Lucidi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hawaii medical journal     Volume:  70     ISSN:  0017-8594     ISO Abbreviation:  Hawaii Med J     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2012-01-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  2984209R     Medline TA:  Hawaii Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-8     Citation Subset:  IM    
Tripler Army Medical Center, Honolulu, USA.
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MeSH Terms
Biological Markers / analysis
Disease Susceptibility
Fertilization in Vitro / adverse effects*,  methods
Follow-Up Studies
Methylenetetrahydrofolate Reductase (NADPH2) / genetics,  metabolism*
Ovarian Hyperstimulation Syndrome / complications,  diagnosis*,  etiology
Ovulation Induction / adverse effects,  methods
Risk Assessment
Thrombophilia / complications,  diagnosis*,  genetics
Reg. No./Substance:
0/Biological Markers; EC Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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