Document Detail

Thrombophilia and its impact on pregnancy.
MedLine Citation:
PMID:  19203641     Owner:  NLM     Status:  MEDLINE    
In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithrombin deficiency, hyperhomocysteinemia and also with factor V Leiden, prothrombin G20210A variation and protein S-deficiency. The association of thrombophilia with pre-eclampsia is still under discussion. A limited number of prospective studies did not reveal an increased risk for pregnancy complications in unselected women with thrombosis risk factors. In a single study low molecular weight heparin seemed to have a positive effect on pregnancy outcome after previous single or recurrent abortions. Experience in prevention of pre-eclampsia by administration of prophylactic heparin is very limited. Data on pregnancy complications in women with known heritable thrombophilia or a history of thrombosis are inconsistent as well. These women usually have a favourable pregnancy outcome. In conclusion, thrombophilia screening might be justified in women with pregnancy loss, and treatment with low molecular weight heparin might be considered for those with pregnancy loss and thrombophilia. Further prospective studies and controlled interventional trials are urgently needed.
Ingrid Pabinger
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Thrombosis research     Volume:  123 Suppl 3     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-10     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S16-21     Citation Subset:  IM    
Department of Internal Medicine I, Medical University of Vienna, Austria.
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MeSH Terms
Abortion, Spontaneous / etiology
Anticoagulants / administration & dosage
Heparin, Low-Molecular-Weight / administration & dosage
Infant, Newborn
Pre-Eclampsia / etiology,  prevention & control
Pregnancy Complications, Cardiovascular / etiology
Pregnancy Complications, Hematologic / etiology*
Pregnancy Outcome
Risk Factors
Thrombophilia / complications*
Thrombosis / complications
Venous Thromboembolism / etiology,  prevention & control
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight

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