| Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 21392126 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well as enormous costs for health care systems. The pathophysiology of CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have not been identified. Objectives We studied the role of thrombophilia in patients referred to a University dermatology department for treatment of CVU. Patients and methods A cohort of 310 patients with active chronic venous leg ulcers (CEAP 6) was stratified into two comparably large groups according to the presence or absence of post-thrombotic syndrome (PTS+; PTS-) as determined using duplex scan and/or phlebography. In addition, several thrombophilia parameters were assessed. Results The prevalence of protein S deficiency and factor V Leiden mutation was significantly higher in PTS+ patients compared with the PTS- group. However, patients in both subgroups revealed high prevalences of thrombophilia (antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation or elevated homocysteine). Conclusion Based on these data, it is conceivable that thrombophilia contributes to the pathogenesis of CVU, possibly through induction of microcirculatory dysregulations. |
| | |
Authors:
|
M Zutt; U Krüger; A Rosenberger; Mp Schön; C Neumann; N von Ahsen; L Kretschmer |
Related Documents
:
|
9463986 - Open access gastroscopy findings are unrelated to the use of aspirin and non-steroidal ... 2371186 - Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unr... 19508616 - Prevalence of 'deep' rectal varices in patients with cirrhosis: an eus-based study. 6711926 - The efficacy of abdominal and pelvic ultrasound in the emergency department. 12357516 - Argatroban anticoagulation during percutaneous coronary intervention in patients with h... 14612286 - Early prediction of severe acute pancreatitis by urinary trypsinogen activation peptide. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
|
Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: - ISSN: 1468-3083 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. |
Affiliation:
|
Department of Dermatology, Venereology and Allergology, University of Göttingen, Göttingen, Germany Department of Genetic Epidemiology, University of Göttingen, Medical School, Göttingen, Germany Department of Clinical Chemistry, University of Göttingen, Göttingen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transverse testicular ectopia with splenogonadal fusion: A case report.
Next Document: Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leu...