Document Detail


Thrombophilia and fetal loss: Lessons from gene targeting in mice.
MedLine Citation:
PMID:  19217483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inherited thrombophilia is recognized as one of the causes of recurrent fetal loss. Yet, the risk of fetal loss in women with thrombophilia is far from absolute. Other risk modifiers are clearly involved, but remain to be identified. The mechanism that translates maternal thrombophilia into pregnancy disorder is also not understood. Genetically engineered mice have led to the development of new insights into the etiology and pathogenesis of thrombophilia-associated fetal loss. These insights are the focus of this review.
Authors:
Rashmi Sood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  123 Suppl 2     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-16     Completed Date:  2009-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S79-84     Citation Subset:  IM    
Affiliation:
Medical College of Wisconsin, Milwaukee, WI, USA. rsood@mcw.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Disease Models, Animal
Factor V / genetics
Female
Fetal Death / blood,  etiology*,  genetics
Humans
Mice
Mice, Knockout
Pregnancy
Pregnancy Complications, Hematologic / blood,  genetics*
Thrombophilia / blood,  complications*,  genetics*
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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