Document Detail


Thrombophilia and early pregnancy loss.
MedLine Citation:
PMID:  22079389     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Early pregnancy loss is the most common pregnancy complication. About 15% of pregnancies result in pregnancy loss and 1% of women experience recurrent miscarriage (more than three consecutive miscarriages). The influence of thrombophilia in pregnancy is a popular research topic in recurrent miscarriage. Both acquired and inherited thrombophilia are associated with a risk of pregnancy failure. Antiphospholipid syndrome is the only thrombophilia known to have a direct adverse effect on pregnancy. Historically, clinical research studying thrombophilia treatment in recurrent miscarriage has been of limited value owing to small participant numbers, poor study design and heterogeneity. The debate on the efficacy of aspirin and heparin has advanced with recently published randomised-controlled trials. Multi-centre collaboration is required to ascertain the effect of thrombophilia on early pregnancy loss and to establish an evidence-based treatment protocol.
Authors:
Kelly McNamee; Feroza Dawood; Roy G Farquharson
Related Documents :
14566039 - Pregnancy in renal transplant recipients: the royal free hospital experience.
14580379 - Augmented pla2 activity in pre-eclamptic decidual tissue--a key player in the pathophys...
18992679 - Soluble and membranous vascular endothelial growth factor receptor-1 in pregnancies com...
12896819 - Trophoblast deportation and the maternal inflammatory response in pre-eclampsia.
12473869 - Skin capillary density changes in normal pregnancy and pre-eclampsia.
11965219 - Conservative management of eclampsia and severe pre-eclampsia--a bangladesh experience.
15354469 - Pregnancy and gingival hyperplasia.
16868549 - Immunology of placentation in eutherian mammals.
19323599 - Meconium aspiration in the midtrimester fetus: an autopsy study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-11
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  -     ISSN:  1532-1932     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, L8 7SS, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Thalassaemia in pregnancy.
Next Document:  Coenzyme Q(10), vitamin E, selenium, and methionine in the treatment of chronic recurrent viral muco...