Document Detail


Thrombophilia and antithrombotic therapy in women with recurrent spontaneous abortions.
MedLine Citation:
PMID:  17694967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the association between thrombophilia and recurrent spontaneous abortions (RSAs) and to evaluate the efficacy of anticoagulant treatment. STUDY DESIGN: All couples with a history of RSAs were studied by immunologic tests and determination of coagulation factors. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia. The control group included 23 women with a history of RSAs and tests positive for thrombophilia who declined to receive medication during pregnancy. RESULTS: All couples with a history of RSAs were studied by immunologic tests and determination of coagulation factors. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia. The control group included 23 women with a history of RSAs and tests positive for thrombophilia who declined to receive medication during pregnancy. CONCLUSION: All couples with RSAs require screening for thrombophilia. Low-molecular-weight heparin and low-dose aspirin daily during pregnancy appear to have a favorable effect on pregnancy outcome in selected women with RSAs and acquired or inherited thrombophilia.
Authors:
Aristidis Deligiannidis; Efthimia Parapanissiou; Panagiotis Mavridis; George Tabakoudis; Antigoni Mavroudi; Theodouli Papastavrou; Panagiotis Tabakoudis
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  52     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-08-14     Completed Date:  2007-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
Affiliation:
Immunology Department and National Peripheral Histocompatibility Center, Hippokration Hospital, Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / drug therapy*,  etiology*
Adult
Aspirin / therapeutic use*
Blood Coagulation Factors / analysis
Female
Fibrinolytic Agents / therapeutic use*
Greece
Heparin, Low-Molecular-Weight / therapeutic use*
Humans
Pregnancy
Pregnancy Outcome
Thrombophilia* / complications,  drug therapy
Treatment Outcome
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Fibrinolytic Agents; 0/Heparin, Low-Molecular-Weight; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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