Document Detail

Thrombophilia and anticoagulation in pregnancy: indications, risks and management.
MedLine Citation:
PMID:  19012185     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Venous thromboembolism (VTE) is a leading cause of maternal morbidity and mortality in pregnancy and the puerperium. To reduce the incidence of VTE, it is helpful to understand the haemostatic changes during pregnancy and to recognise thrombophilic states. According to the individual risk profile a prophylactic or therapeutic anticoagulation needs to be considered. METHODS: A narrative, non-systematic overview of articles published in English, German or French over the past three decades with an emphasis on manuscripts from 2003 to 2008. RESULTS: Heparins are the main agents used for anticoagulation during pregnancy. Low-molecular-weight heparins have more advantages than unfractionated heparin and should be preferred. Vitamin-K antagonists are not recommended in this condition as first-line treatment because of the risk for embryopathy and fetal bleeding, but they can be given under certain conditions. Subgroups of patients, such as women with prosthetic heart valves, require special attention. Adverse pregnancy outcomes due to hereditary thrombophilia are new indications for use of anticoagulants during pregnancy. CONCLUSIONS: National and international guidelines on prevention and treatment of thromboembolism are helpful in applying the proper regimen in pregnant women.
Céline Montavon; Irene Hoesli; Wolfgang Holzgreve; Dimitrios A Tsakiris
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Review    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  21     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  685-96     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Hospital of Basel, Basel, Switzerland.
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MeSH Terms
Anticoagulants / adverse effects*,  contraindications,  therapeutic use*
Blood Coagulation / drug effects,  physiology
Models, Biological
Pregnancy / physiology
Pregnancy Complications, Hematologic / diagnosis,  drug therapy,  etiology
Risk Assessment
Risk Factors
Thrombophilia / diagnosis*,  drug therapy*,  etiology
Reg. No./Substance:

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