Document Detail

Thrombophilia and adverse maternal-perinatal outcome.
MedLine Citation:
PMID:  17082680     Owner:  NLM     Status:  MEDLINE    
A recent review of the literature on thrombophilia and adverse pregnancy outcome (APO) reveals contradictory findings. We have limited our review of literature mostly to the most recent decade. On the basis of our review, screening for thrombophilias with a history of APO (preeclampsia, abruptio placenta, intrauterine growth restriction, and fetal loss) is not clear. There are retrospective and prospective studies that recommend testing for genetic and acquired markers of thrombophilia for those with the enumerated APO. The rationale for such recommendation is to use heparin prophylaxis in subsequent pregnancies. However, this recommendation is not based on randomized trials. Hence, a randomized double-blinded controlled trial is urgently needed to evaluate the benefit of heparin during pregnancy in women with a history of APO in association with thrombophilia.
Caroline L Stella; Baha M Sibai
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  49     ISSN:  0009-9201     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-07-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  850-60     Citation Subset:  IM    
University of Cincinnati College of Medicine, Division of Maternal-Fetal Medicine, Cincinnati, Ohio 45267-0526, USA.
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MeSH Terms
Abortion, Spontaneous / etiology
Abruptio Placentae / etiology
Anticoagulants / therapeutic use
Heparin / therapeutic use
Pre-Eclampsia / etiology
Pregnancy Complications, Hematologic*
Pregnancy Outcome*
Randomized Controlled Trials as Topic
Thrombophilia / complications*
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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