Document Detail


Thrombophilia and activated protein C resistance.
MedLine Citation:
PMID:  9841693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to classic vascular insults such as inflammation, trauma, malignancy, and surgery, a number of hereditary coagulation defects predispose patients to a wide array of thrombotic complications. A novel genetic defect in factor V allowing for resistance to its cleavage by activated protein C has recently been implicated in a significant number of cases of familial thrombophilia. A brief case report and review of the literature is presented to familiarize surgeons to this important and quite frequent cause of hypercoagulability.
Authors:
C H Selzman; T A Whitehill; W C Krupski
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  12     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-22     Completed Date:  1998-12-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  601-4     Citation Subset:  IM    
Affiliation:
Section of Vascular Surgery, University of Colorado Health Sciences Center, Denver, CO, USA.
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MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / complications*,  genetics
Adolescent
Humans
Male
Thrombophilia / etiology*
Venous Thrombosis / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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