Document Detail

Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension.
MedLine Citation:
PMID:  7501335     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure the circulating levels of thrombomodulin in women with preeclampsia, gestational hypertension, and chronic hypertension. METHODS: Serum levels of thrombomodulin were measured in 34 women with preeclampsia, 15 with gestational hypertension, 11 with chronic hypertension, and 34 normotensive pregnant women in the third trimester. Preeclampsia, gestational hypertension, and chronic hypertension were defined by ACOG criteria. Soluble thrombomodulin antigen was measured by a two-site enzyme-linked immunosorbent assay. RESULTS: Mean (+/- standard error) serum thrombomodulin levels were significantly higher in patients with preeclampsia (69.7 +/- 6.3 ng/mL) than in those with gestational hypertension (46.0 +/- 3.2 ng/mL) or chronic hypertension (46.2 +/- 3.3 ng/mL), and normotensive controls (50.1 +/- 3.1 ng/mL). There were no significant differences among the gestational hypertension, chronic hypertension, and normotensive control groups. CONCLUSION: Thrombomodulin may serve as a clinically meaningful marker to differentiate preeclampsia from other forms of hypertensive disorders in pregnancy.
C D Hsu; J A Copel; S F Hong; D W Chan
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  86     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  897-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.
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MeSH Terms
Biological Markers / blood
Chronic Disease
Diagnosis, Differential
Hypertension / blood*,  diagnosis
Pre-Eclampsia / blood*,  diagnosis
Pregnancy Complications, Cardiovascular / blood*,  diagnosis
Thrombomodulin / analysis*
Reg. No./Substance:
0/Biological Markers; 0/Thrombomodulin

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