| Thrombomodulin in systemic lupus erythematosus: association with clinical and laboratory parameters. | |
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MedLine Citation:
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PMID: 10651075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombomodulin is an endothelial cell membrane glycoprotein and is detected in plasma and serum after endothelial injury. In our study comprising 311 patients with systemic lupus erythematosus (SLE) clinical and laboratory associations of elevated thrombomodulin serum concentrations were examined. Elevated thrombomodulin concentrations were detected in 7.1% of the SLE patients and were associated with nephritis including the laboratory parameters proteinuria and erythrocyte casts, vasculitis and neurological involvement of the central nervous system. These correlations remained significant after consideration of the influence of renal function. In SLE, the serum thrombomodulin concentration may become a marker to monitor damage of endothelial cells and involvement of the central nervous system. |
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Authors:
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T Witte; K Hartung; C Sachse; M Fricke; S Buyny; H Deicher; J R Kalden; H J Lakomek; H H Peter; R E Schmidt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rheumatology international Volume: 19 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-17 Completed Date: 2000-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: GERMANY |
Other Details:
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Languages: eng Pagination: 15-8 Citation Subset: IM |
Affiliation:
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Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany. witte.torsten@mh.hannover.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enzyme-Linked Immunosorbent Assay Humans Lupus Erythematosus, Systemic / blood*, physiopathology Thrombomodulin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Thrombomodulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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