Document Detail

Thrombolytics and myocardial infarction.
MedLine Citation:
PMID:  21070617     Owner:  NLM     Status:  In-Data-Review    
Coronary artery disease is the single leading cause of death in the United States. Occlusion of the coronary artery was identified to be the cause of myocardial infarction almost a century ago. Following a series of investigations, streptokinase was discovered and demonstrated to be beneficial for the treatment of patients with acute myocardial infarction in terms of reducing short- and long-term mortality. Newer agents including tissue plasminogen activators such as alteplase, reteplase, tenecteplase were developed subsequently. In the present era, thrombolytic therapy and primary percutaneous coronary intervention has revolutionized the way patients with acute myocardial infarction are managed resulting in significant reduction in cardiovascular death. This article provides an overview of the various thrombolytic agents utilized in the management of patients with acute myocardial infarction.
Vijayalakshmi Kunadian; C Michael Gibson
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Publication Detail:
Type:  Journal Article     Date:  2010-11-11
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  30     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  e81-8     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Cardiothoracic Division, The James Cook University Hospital, Middlesbrough, UK Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
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