Document Detail

Thrombolytic therapy for stroke.
MedLine Citation:
PMID:  1854597     Owner:  NLM     Status:  MEDLINE    
Thrombolytic therapy has recently been shown to be beneficial in the setting of acute myocardial infarction, and thrombolysis resulting in vascular recanalization has been achieved in several other human disease states, including stroke. Advances in the understanding of the fibrinolytic system have led to the development of several new and distinctive thrombolytic strategies. Animal studies of stroke have been encouraging with regard to arterial recanalization and safety. Clinically, the availability of brain computed tomography has allowed pilot studies to proceed by providing rapid identification of patients with nonhemorrhagic stroke. Arterial recanalization has been demonstrated in patients with ischemic stroke following the administration of any one of several thrombolytic drugs. Placebo-controlled trials have not been completed, and so clinical benefit has not been established. Even though the development of brain hemorrhage has been an infrequent complication, the very high morbidity and mortality have been worrisome. Ironically, thrombolytic therapy holds promise for treatment of subarachnoid hemorrhage and perhaps also for spontaneous intracerebral hemorrhage. Human studies have been limited, but complications have been modest, and clinical outcomes have been encouraging.
T Brott
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cerebrovascular and brain metabolism reviews     Volume:  3     ISSN:  1040-8827     ISO Abbreviation:  Cerebrovasc Brain Metab Rev     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8910172     Medline TA:  Cerebrovasc Brain Metab Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-113     Citation Subset:  IM    
Department of Neurology, University of Cincinnati College of Medicine, OH 45267-0525.
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MeSH Terms
Cerebral Angiography
Cerebrovascular Disorders / drug therapy*,  radiography
Middle Aged
Streptokinase / therapeutic use
Thrombolytic Therapy* / adverse effects
Time Factors
Tomography, X-Ray Computed
Urokinase-Type Plasminogen Activator / therapeutic use
Reg. No./Substance:
EC 3.4.-/Streptokinase; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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