Document Detail

Thrombolytic therapy for massive pulmonary embolism in a patient with a known intracranial tumor.
MedLine Citation:
PMID:  16855059     Owner:  NLM     Status:  MEDLINE    
The objective was to describe and review the use of thrombolytic therapy in a patient with an intracranial tumor and massive pulmonary embolism. This is the first reported case of a patient with a known glioblastoma multiforme and massive pulmonary embolism who was successfully treated with alteplase. Pulmonary embolism was demonstrated by a ventilation-perfusion scan and transthoracic echocardiogram with repeat studies demonstrating resolution of the thromboembolism and reperfusion of pulmonary vasculature. A review of the literature revealed that the incidence of intracranial hemorrhage with thrombolysis is <3% and compares favorably with the much higher mortality rate of 25% to >/=50% in patients with hemodynamically unstable pulmonary emboli. The benefit of thrombolysis may outweigh the risks of intracranial hemorrhage in these patients, and careful consideration for its use in these patients is warranted.
Steve Han; Craig Chaya; Guy W Soo Hoo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  21     ISSN:  0885-0666     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-07-20     Completed Date:  2006-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA.
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MeSH Terms
Brain Neoplasms / complications*
Drug Therapy, Combination
Fibrinolytic Agents / contraindications,  therapeutic use*
Glioblastoma / complications*
Heparin / therapeutic use*
Pulmonary Embolism / complications,  drug therapy*
Thrombolytic Therapy
Tissue Plasminogen Activator / contraindications,  therapeutic use*
Reg. No./Substance:
0/Fibrinolytic Agents; 9005-49-6/Heparin; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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