| Thrombolytic therapy in vertebrobasilar occlusion. | |
| | |
MedLine Citation:
|
PMID: 1343857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Since 1983 at the Alfred Hospital 4 patients with thrombotic or embolic vertebrobasilar occlusions have been treated with intra-arterial streptokinase (SK) infusions for the effects of persisting brainstem ischaemia despite anticoagulation with heparin. In 3 cases there was immediate and dramatic neurological improvement, in all cases associated with arteriographically demonstrated reperfusion of a blocked vessel. Two of these patients suffered further thromboembolic vertebral or basilar artery occlusions (3 days and 2 years later) but recovered fully without further thrombolytic therapy. The other patient was given intra-arterial SK 12 days after an apparently completed brainstem stroke: the therapy failed to cause reperfusion of a vertebral occlusion or produce any clinical improvement. Complications from the therapy were nausea requiring the termination of the SK infusion in one case, easily controlled bleeding from a recent surgical wound, and a clinically insignificant haemorrhagic transformation of cerebellar infarction in a third. The benefits of thrombolytic therapy in vertebrobasilar ischaemia and the dose of streptokinase required are discussed. |
| | |
Authors:
|
D Thyagarajan; R J Stark; J Frayne; B S Gilligan; N Sacharias |
Related Documents
:
|
10650237 - Successful cricothyrotomy after thrombolytic therapy for acute myocardial infarction: a... 7561557 - Thrombolytic therapy in 1995. 2112877 - Evaluation of the effect of thrombolytic treatment on infarct size and left ventricular... 1636587 - Assessment of reperfusion after thrombolytic therapy for myocardial infarction. 3747587 - Effects of "duration" of reperfusate administration versus reperfusate "dose" on region... 2991357 - Tomographic gated blood pool radionuclide ventriculography: analysis of wall motion and... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical and experimental neurology Volume: 29 ISSN: 0196-6383 ISO Abbreviation: Clin Exp Neurol Publication Date: 1992 |
Date Detail:
|
Created Date: 1994-03-31 Completed Date: 1994-03-31 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7909724 Medline TA: Clin Exp Neurol Country: AUSTRALIA |
Other Details:
|
Languages: eng Pagination: 129-42 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Alfred Hospital, Melbourne. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cerebral Angiography Female Humans Injections, Intra-Arterial Male Middle Aged Streptokinase / therapeutic use Thrombolytic Therapy* / adverse effects Tomography, X-Ray Computed Vertebrobasilar Insufficiency / radiography, therapy* |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predicting survival after stroke: experience from the Perth Community Stroke Study.
Next Document: Confounding factors in non-invasive tests of neurovascular function in diabetes mellitus.