Document Detail

Thrombolytic therapy and balloon catheter thrombectomy in experimental femoral artery thrombosis: effect on arterial wall morphology.
MedLine Citation:
PMID:  7787354     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine vessel wall architectural changes after lytic therapy and balloon catheter thrombectomy in experimentally thrombosed arteries. MATERIALS AND METHODS: Bilateral 5-cm femoral artery occlusions were created by ligation in 14 dogs. Two dogs served as controls, and 12 animals underwent balloon catheter thrombectomy on the left and lytic therapy with urokinase on the right either 24 hours (group 1, n = 6) or 7 days (group 2, n = 6) after creation of the occlusion. After treatment, the area of thrombosis was subjected to light and scanning electron microscopy. RESULTS: The IEL was intact in all lysed arteries. IEL fractures were present in 11 of 12 arteries treated with thrombectomy. For group 1 arteries, average luminal area after thrombectomy was 5.63 mm2 +/- 0.66 versus 1.94 mm2 +/- 0.7 after lytic therapy (P < .007). Mean control artery luminal area was 2.86 mm2 +/- 0.52. Similar differences were found in group 2 arteries. With lytic therapy, scanning electron microscopy grading revealed surfaces to be intact in group 1, but moderate injury was exhibited in group 2. All arteries treated with thrombectomy had severe injury. CONCLUSIONS: Lysis of acute thrombi (group 1) preserved arterial wall architecture, with an intact IEL and no endothelial injury. Lysis of chronic thrombi (group 2) was associated with mild to moderate injury. Catheter thrombectomy caused severe injury regardless of the time of intervention. These results may help explain the poor long-term patency observed after these interventions.
M Wengrovitz; D A Healy; R R Gifford; R G Atnip; B L Thiele
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  6     ISSN:  1051-0443     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:    1995 Mar-Apr
Date Detail:
Created Date:  1995-07-25     Completed Date:  1995-07-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Section of Vascular Surgery, Pennsylvania State University College of Medicine, Hershey, USA.
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MeSH Terms
Balloon Dilatation* / adverse effects
Elastic Tissue / pathology,  ultrastructure
Endothelium, Vascular / pathology,  ultrastructure
Femoral Artery / pathology*,  surgery,  ultrastructure
Microscopy, Electron, Scanning
Thrombectomy / adverse effects,  methods*
Thrombolytic Therapy*
Thrombosis / drug therapy*,  pathology,  surgery*
Tunica Intima / pathology,  ultrastructure
Urokinase-Type Plasminogen Activator / administration & dosage,  therapeutic use*
Vascular Patency
Reg. No./Substance:
EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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