| Thrombolytic therapy and balloon catheter thrombectomy in experimental femoral artery thrombosis: effect on arterial wall morphology. | |
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MedLine Citation:
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PMID: 7787354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine vessel wall architectural changes after lytic therapy and balloon catheter thrombectomy in experimentally thrombosed arteries. MATERIALS AND METHODS: Bilateral 5-cm femoral artery occlusions were created by ligation in 14 dogs. Two dogs served as controls, and 12 animals underwent balloon catheter thrombectomy on the left and lytic therapy with urokinase on the right either 24 hours (group 1, n = 6) or 7 days (group 2, n = 6) after creation of the occlusion. After treatment, the area of thrombosis was subjected to light and scanning electron microscopy. RESULTS: The IEL was intact in all lysed arteries. IEL fractures were present in 11 of 12 arteries treated with thrombectomy. For group 1 arteries, average luminal area after thrombectomy was 5.63 mm2 +/- 0.66 versus 1.94 mm2 +/- 0.7 after lytic therapy (P < .007). Mean control artery luminal area was 2.86 mm2 +/- 0.52. Similar differences were found in group 2 arteries. With lytic therapy, scanning electron microscopy grading revealed surfaces to be intact in group 1, but moderate injury was exhibited in group 2. All arteries treated with thrombectomy had severe injury. CONCLUSIONS: Lysis of acute thrombi (group 1) preserved arterial wall architecture, with an intact IEL and no endothelial injury. Lysis of chronic thrombi (group 2) was associated with mild to moderate injury. Catheter thrombectomy caused severe injury regardless of the time of intervention. These results may help explain the poor long-term patency observed after these interventions. |
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Authors:
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M Wengrovitz; D A Healy; R R Gifford; R G Atnip; B L Thiele |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 6 ISSN: 1051-0443 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 1995 Mar-Apr |
Date Detail:
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Created Date: 1995-07-25 Completed Date: 1995-07-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 205-10 Citation Subset: IM |
Affiliation:
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Section of Vascular Surgery, Pennsylvania State University College of Medicine, Hershey, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Balloon Dilatation* / adverse effects Dogs Elastic Tissue / pathology, ultrastructure Endothelium, Vascular / pathology, ultrastructure Femoral Artery / pathology*, surgery, ultrastructure Male Microscopy, Electron, Scanning Thrombectomy / adverse effects, methods* Thrombolytic Therapy* Thrombosis / drug therapy*, pathology, surgery* Tunica Intima / pathology, ultrastructure Urokinase-Type Plasminogen Activator / administration & dosage, therapeutic use* Vascular Patency |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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