| Thrombolytic therapy for arterial thrombosis. | |
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MedLine Citation:
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PMID: 10468146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The major development in the field of intra-arterial thrombolytic therapy over the past year was the publication of the phase II results of the Thrombolysis or Peripheral Arterial Surgery study, which compared the safety and efficacy of catheter-directed thrombolysis and surgery as the initial treatment of acute arterial occlusion. The results are consistent with those of the prior two studies, showing little or no difference between surgery and thrombolysis in the most important endpoints of survival and amputation rate. Patients receiving thrombolysis needed fewer interventions, but this benefit was balanced by increased bleeding complications. Additional studies have, therefore, been aimed at identifying subsets of patients with acute arterial occlusion who are most likely to benefit from thrombolysis. These studies have refined the selection criteria for use of thrombolytic therapy over the past year. In addition, studies have been published evaluating new drug doses and regimens aimed at broadening the scope of thrombolytic therapy in patients with acute arterial occlusion. |
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Authors:
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C K Shortell; C W Francis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in hematology Volume: 6 ISSN: 1065-6251 ISO Abbreviation: Curr. Opin. Hematol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-05 Completed Date: 1999-10-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9430802 Medline TA: Curr Opin Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 309-13 Citation Subset: IM |
Affiliation:
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University of Rochester School of Medicine and Dentistry, New York 14642, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
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drug therapy* Humans Thrombolytic Therapy* Thrombosis / drug therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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