| Thrombolytic therapy for acute arterial occlusion. | |
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MedLine Citation:
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PMID: 7583985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The standard treatment of peripheral arterial occlusion has been operative, employing embolectomy, thrombectomy, or bypass grafting to restore blood flow to the compromised extremity. Intra-arterial thrombolysis has been advocated as an initial intervention designed to unmask the anatomic lesion responsible for the occlusive event, with a directed or endovascular modality thereafter. Four thrombolytic agents are in clinical use: streptokinase, urokinase, recombinant tissue plasminogen activator, and acylated plasminogen streptokinase activator complex. The agents differ with respect to efficacy of thrombolysis, fibrin specificity, and cost. At present, urokinase is the most widely used. Recent randomized clinical trials suggest a benefit of thrombolytic therapy in the initial management of acute peripheral arterial occlusion, with improved patient survival and similar amputation rates compared with immediate open intervention. Each modality has its place in specific patient subcategories; the determination of which patients are best served by a specific modality awaits the results of large clinical trials. |
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Authors:
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K Ouriel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in general surgery Volume: - ISSN: 1065-6243 ISO Abbreviation: Curr Opin Gen Surg Publication Date: 1994 |
Date Detail:
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Created Date: 1995-12-18 Completed Date: 1995-12-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9314670 Medline TA: Curr Opin Gen Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Rochester Medical Center, NY 14642-8410, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Arterial Occlusive Diseases / drug therapy*, radiography Blood Vessel Prosthesis Clinical Trials as Topic Graft Occlusion, Vascular / drug therapy, radiography Humans Ischemia / drug therapy*, radiography Leg / blood supply* Thrombolytic Therapy / methods* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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