Document Detail

Thrombolytic agents for arterial and venous thromboses in neonates.
MedLine Citation:
PMID:  15674942     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Clinically symptomatic thromboses are infrequent but serious complications in infants undergoing intensive care. Most are related to central vascular catheters. Symptomatic thrombosis may cause severe morbidity due to irreversible organ damage and also loss of limbs.
OBJECTIVES: To assess the efficacy and safety of thrombolytic agents in neonatal arterial and venous thromboses.
SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2004), MEDLINE (January 1966 to January 2004), EMBASE (January 1980 to January 2004), and CINAHL (January 1982 to January 2004). We also contacted authors of appropriate review articles.
SELECTION CRITERIA: Randomised controlled trials (RCT) and quasi RCT comparing thrombolytic agents with either heparin or observation in neonates with symptomatic neonatal arterial and venous thromboses were included.
DATA COLLECTION AND ANALYSIS: Two reviewers independently searched for eligible trials. No eligible studies were found even after contacting authors of review articles for details of any unpublished trials.
MAIN RESULTS: No randomised controlled trials (RCT) or quasi-RCT were found.
AUTHORS' CONCLUSIONS: No conclusions could be made as no eligible studies were found. It is time that a randomised controlled trial was performed comparing thrombolytic therapy to heparin therapy to aid neonatologists in the treatment of arterial and venous thromboses.
C M John; C Harkensee
Publication Detail:
Type:  Journal Article; Review     Date:  2005-01-25
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2005  
Date Detail:
Created Date:  2005-01-27     Completed Date:  2005-05-27     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD004342     Citation Subset:  IM    
Paediatrics, Neonatal Unit, Liverpool Womens Hospital, crown Street, Liverpool L8 7SS, Liverpool Womens Hospital, Crown street, Liverpool, Merseyside, UK, L8 7SS.
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MeSH Terms
Fibrinolytic Agents / therapeutic use*
Infant, Newborn
Thrombolytic Therapy*
Thrombosis / drug therapy*
Venous Thrombosis / drug therapy
Reg. No./Substance:
0/Fibrinolytic Agents

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