| Thrombolysis in submassive pulmonary embolism, prudent or puerile? | |
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MedLine Citation:
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PMID: 23354859 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Pulmonary embolism (PE) remains one of the leading causes of cardiovascular mortality. The safety and efficacy of thrombolytic therapy using tissue-type plasminogen activator (tPA) for acute PE in clinical practice remain unclear. We describe a case of life-threatening submassive PE causing extreme refractory hypoxaemia, where thrombolysis was successfully administered. Current consensus suggests that patients with features of hemodynamic instability as a result of an acute PE, that is, massive PE, should receive thrombolysis. Patients, not in shock however, but with evidence of right-ventricular (RV) dysfunction echocardiographically, that is, submassive PE may also benefit. Serum troponin and brain-type natriuretic peptide have been suggested as biomarkers of RV injury that may identify a subset of submassive PE patients who may particularly benefit from thrombolytic therapy. The clinical response of this patient to thrombolysis is important, as it may identify a subgroup of patients with submassive PE who warrant this intervention. |
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Authors:
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Aamer Rehman; Shafaq Yousaf; Atul Chugh |
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Publication Detail:
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Type: Journal Article Date: 2013-01-24 |
Journal Detail:
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Title: BMJ case reports Volume: 2013 ISSN: 1757-790X ISO Abbreviation: BMJ Case Rep Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101526291 Medline TA: BMJ Case Rep Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, University of Louisville, Louisville, Kentucky, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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