| Thrombolysis effect of a novel targeted microbubble with low-frequency ultrasound in vivo. | |
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MedLine Citation:
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PMID: 18690359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clot-targeted microbubbles (TMB) were developed based on oligopeptide specific to the glycoprotein IIb/IIIa receptor on active platelets. In this study, we aimed to elucidate the thrombolysis effect of this TMB in both intraarterial and intravenous application and compare the clot lysis efficiency of the TMB and untargeted microbubbles(UTMB) in presence of external low frequency ultrasound (LFUS) (800 kHz, 2.4 w/cm(2), pulse-wave). An acute arterial occlusion model was induced in rabbits by blocking the common carotid artery with an autogenous clot. Animals were randomized to five groups to receive the following treatment: 1) intra-arterial TMB and LFUS (IA TMB/LFUS); 2) intravenous TMB and LFUS (IV TMB/LFUS); 3) intravenous untargeted-microbubbles and LFUS (IV UTMB/LFUS); 4) LFUS only; 5) intra-arterial normal saline (NS) control. Declotting score and a variation of thrombolysis-in-myocardial-infarction (TIMI) flow scale were applied to assess clot clearance and flow restore according to the angiogram. IA TMB/LFUS treatment produced highest declotting score (3.5 +/- 0.53) and success rate (100%). IV TMB/LFUS treatment produced a higher declotting score (1.95 +/- 1.12) than LFUS treatment (0.53 +/- 0.38) (P = 0.026). and higher TIMI (1.94 +/- 0.62 vs. 0.47 +/- 0.44, P = 0.020). When administrated intravenously, TMB/LFUS created a higher declotting score (1.95 +/- 1.12) than that of UTMB/LFUS (0.61 +/- 0.43) (P = 0.033). The superiority was observed in TIMI also (1.94 +/- 0.62 vs. 0.72 +/- 0.25, P = 0.041). The results demonstrate that either intra-arterial or intravenous TMB is effective in clearing clot in-vivo model. The TMB showed advantage over UTMB in systemic administration. |
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Authors:
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Bing Wang; Li Wang; Xiao-Bo Zhou; Ya-Min Liu; Mei Wang; Hao Qin; Chong-Bao Wang; Ju Liu; Xiao-Jiang Yu; Wei-Jin Zang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 100 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 356-61 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Medicine, Xi'an Jiaotong University, Xi'an, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Angiography Animals Carotid Artery, Common Disease Models, Animal Femoral Artery Fibrin Fibrinogen Degradation Products / metabolism Fibrinogen / metabolism Microbubbles Partial Thromboplastin Time Prothrombin Time Rabbits Thrombolytic Therapy / instrumentation*, methods* Thrombosis / therapy*, ultrasonography* Ultrasonography, Interventional* |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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