Document Detail


Thrombolysis for acute stroke under antiplatelet therapy: safe enough to be beneficial?
MedLine Citation:
PMID:  18665145     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Controversy exists over whether chronic antiplatelet therapy in patients with acute ischemic stroke is a contraindication to treatment with tissue plasminogen activator (tPA). Antiplatelets impair thrombocyte function and might, therefore, increase the risk of symptomatic intracerebral hemorrhage (SICH) after intravenous thrombolysis. This Practice Point commentary discusses a recent study by Uyttenboogaart et al. that aimed to further explore the interactions between antiplatelet and tPA therapies. The single-center study, which included 301 consecutive patients with ischemic stroke, found that the incidence of SICH was indeed increased among patients who were pretreated with antiplatelets, but that these patients nevertheless had a greater net benefit of thrombolysis than did those who had not received previous antiplatelet therapy. The commentary authors consider the study's shortcomings, but conclude that the widespread practice of using tPA in the presence of antiplatelet therapy is justified.
Authors:
Werner Hacke; Christoph Lichy
Related Documents :
20672495 - Evaluation of neurogenic dysphagia in iraqi patients with acute stroke.
18830025 - Proinflammatory reactants as determinants of stroke severity in elderly.
20651265 - Microbleeds and the risk of recurrent stroke.
7457205 - The outcome of patients with transient ischemic attacks and stroke treated with anticoa...
1575575 - A new method for the radiological assessment of vertebral squaring in ankylosing spondy...
11465435 - Autologous blood transfusion in oral and maxillofacial surgery patients with the use of...
Publication Detail:
Type:  Comment; Journal Article     Date:  2008-07-29
Journal Detail:
Title:  Nature clinical practice. Neurology     Volume:  4     ISSN:  1745-8358     ISO Abbreviation:  -     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101261799     Medline TA:  Nat Clin Pract Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  474-5     Citation Subset:  -    
Affiliation:
Department of Neurology, University of Heidelberg, Heidelberg, Germany. werner.hacke@med.uni-heidelberg.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections
Comment On:
Arch Neurol. 2008 May;65(5):607-11   [PMID:  18332238 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Continuous intrathecal baclofen infusion for intractable spastic cerebral palsy--is it worth it?
Next Document:  Treatment recommendations for migraine.