Document Detail

Thrombolysis for acute arterial occlusion.
MedLine Citation:
PMID:  20434297     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Acute leg ischemia is one of the most challenging and dangerous conditions in vascular surgical practice and carries a high risk of amputation and death when left untreated. This article provides an overview of the currently held opinions on the role of catheter-based thrombolytic therapy in patients with acute leg ischemia.
METHODS: A systematic review of literature from 1980 to 2009 was performed. The literature analyzed included randomized trials, large single-center case series, and review articles.
RESULTS: Three large randomized trials and 14 review articles were identified. Pharmacologic aspects and the results of thrombolytic therapy, as well as indications, contraindications, and complications are described.
CONCLUSIONS: Catheter-directed thrombolysis can be considered a complementary and not a competing technology with surgical or percutaneous revascularization, with an acceptably low complication rate.
Jos C van den Berg
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  52     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-08-31     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  512-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Service of Interventional Radiology, Ospedale Regionale di Lugano, sede Civico, Lugano, Switzerland.
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MeSH Terms
Acute Disease
Arterial Occlusive Diseases / complications,  drug therapy*,  physiopathology
Evidence-Based Medicine
Fibrinolytic Agents / therapeutic use*
Ischemia / drug therapy*,  etiology,  physiopathology
Lower Extremity / blood supply*
Odds Ratio
Patient Selection
Randomized Controlled Trials as Topic
Risk Assessment
Risk Factors
Thrombolytic Therapy* / adverse effects
Treatment Outcome
Vascular Patency
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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