| Thrombogenicity of various endovascular stent types: an in vitro evaluation. | |
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MedLine Citation:
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PMID: 12397125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to evaluate the thrombogenicity of different peripheral stent types in a standardized in vitro model with fresh human whole blood. MATERIALS AND METHODS: Different stents (N = 77; n = 7 of each of 11 types) were implanted in polyvinyl chloride tubing loops and filled with donor blood samples. After 120 minutes of blood circulation, the thrombin-antithrombin III complex (TAT) levels, beta-thromboglobulin (beta-TG) levels, and platelet counts were assessed. RESULTS: After 2 hours, significant differences were seen. TAT values (+/- SD) with the investigated stents were 31 micro g/mL +/- 20 (control, no stent), 328 micro g/mL +/- 206 (Saxx stent, peripheral medium CrNi31 L), 651 micro g/mL +/- 760 (Palmaz Corinthian Stent, 316 L stainless steel, electropolished), 1,609 micro g/mL +/- 1,264 (Palmaz Corinthian Stent, 316 L stainless steel, not electropolished), 810 micro g/mL +/- 578 (Palmaz Schatz long medium stent), 569 micro g/mL +/- 347 (Smart Nitinol stent), 1,037 micro g/mL +/- 577 (Megalink peripheral stent), 543 micro g/mL +/- 487 (peripheral stent, electropolished), 1,674 micro g/mL +/- 2,057 (peripheral stent, not electropolished), 3,128 micro g/mL +/- 1,812 (SelfX Nitinol stent, polished), 5,897 micro g/mL +/- 2,380 (SelfX Nitinol stent, unpolished), and 1,458 micro g/mL +/- 887 (bridge stent). The platelet count (x1,000/ micro L +/- SD) was 218 +/- 35 (control, no stent), 188 +/- 22 (Saxx stent), 187 +/- 20 (Palmaz Corinthian stent, electropolished), 135 +/- 37 (Palmaz Corinthian stent, not electropolished), 170 +/- 24 (Palmaz Schatz stent), 180 +/- 36 (Smart Nitinol stent), 159 +/- 26 (Megalink peripheral stent), 173 +/- 17 (peripheral stent, electropolished), 133 +/- 51 (peripheral stent, not electropolished), 123 +/- 37 (SelfX Nitinol stent, polished), 52 +/- 27 (SelfX Nitinol stent, unpolished), and 130 +/- 31 (bridge stent). CONCLUSION: This standardized study showed a wide range of platelet activation after stent implantation. Electropolishing clearly reduced the thrombogenicity of the stents. |
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Authors:
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Gunnar Tepe; Hans P Wendel; Sascha Khorchidi; Jörg Schmehl; Jakub Wiskirchen; Benjamin Pusich; Claus D Claussen; Stephan H Duda |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 13 ISSN: 1051-0443 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-24 Completed Date: 2003-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1029-35 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University of Tübingen, Hoppe-Seyler. Str. 3, 72076 Tübingen, Germany. gunnar.tepe@med.uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alloys Antithrombin III Humans Microscopy, Electron, Scanning Peptide Hydrolases / blood Platelet Activation Platelet Count Stainless Steel Stents / adverse effects* Surface Properties Thrombosis / etiology* beta-Thromboglobulin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Alloys; 0/antithrombin III-protease complex; 0/beta-Thromboglobulin; 12597-68-1/Stainless Steel; 52013-44-2/nitinol; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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