| Thrombogenic performance of a st. Jude bileaflet mechanical heart valve in a sheep model. | |
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MedLine Citation:
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PMID: 16436887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sheep model is preferred for chronic evaluation of prosthetic heart valves, surgical techniques, and endocardiographic studies. A bileaflet mechanical heart valve (MHV) was implanted into a sheep model to study its in vivo performance and to evaluate the thrombogenic potential of the valve. Transesophageal echocardiography and transcranial Doppler ultrasonography measurements were conducted before and after the valve implantation. Platelet activity state (PAS) assay measurements were also conducted before and after the implantation surgery. After sheep euthanasia, the MHV was explanted and scanning electron microscopy (SEM) was performed on the explanted valve to examine changes to the MHV surface. Tissue blocks were taken from the sheep brain, left ventricle, aorta, spleen, and lung lobes for histological examination. Our results indicated that after the MHV implantation, more embolic signals were detected in the sheep carotid artery, increasing monotonously as a function of implantation time. Echocardiographic parameters including blood aortic velocity, transvalvular pressure gradient, and velocity time integral increased. PAS increased significantly after valve implantation. SEM pictures demonstrated calcium and phosphate deposition on the valve surfaces. Histological examination demonstrated hemorrhage in the lung tissue, pulmonary thrombosis, and osteogenesis in heart tissue. |
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Authors:
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Wei Yin; Irvin B Krukenkamp; Adam E Saltman; Glenn Gaudette; Krishnamurthy Suresh; Oscar Bernal; Jolyon Jesty; Danny Bluestein |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 52 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-01-26 Completed Date: 2006-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 28-33 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Division of Hematology, Stony Brook University, Stony Brook, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / physiopathology Aortic Valve / surgery, ultrasonography Blood Flow Velocity Blood Platelets / metabolism Calcium / metabolism Carotid Arteries / physiopathology Echocardiography, Transesophageal Female Follow-Up Studies Heart Valve Prosthesis / adverse effects* Heart Valve Prosthesis Implantation / adverse effects* Microscopy, Electron, Scanning Phosphates / metabolism Platelet Activation Prosthesis Design Sheep Thrombosis / etiology*, pathology Time Factors Treatment Outcome Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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