Document Detail

Thromboembolism and resistance to activated protein C in children with underlying cardiac disease.
MedLine Citation:
PMID:  8917233     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In the majority of cases, resistance to activated protein C is caused by the point mutation Arg506 to Gln in the factor V gene and has emerged as the most important hereditary cause of thromboembolism. METHODS: To determine to what extent resistance to activated protein C was present in children with thromboembolism and underlying cardiac disease, its occurrence was retrospectively investigated. By using a method based on activated partial thromboplastin time, with DNA technique derived from the polymerase chain reaction, we investigated nine children with underlying cardiac disease in whom thromboembolism had previously occurred. RESULTS: Heterozygous Arg506-to-Gln mutation in the factor V gene was diagnosed in five of the nine children investigated. In addition, protein C type I deficiency w as found in three patients, and two of the nine children showed increased lipoprotein (a) plasma values. Risk factors were present in all children with symptoms. CONCLUSIONS: These data indicate that deficiencies in the protein C anticoagulant pathway are likely to play an important role in the early manifestation of thromboembolism in children with underlying cardiac disease.
B Kohlhase; H Vielhaber; H G Kehl; D Kececioglu; H G Koch; U Nowak-Göttl
Related Documents :
3768223 - Isoflurane does not reduce aortic peak flow velocity in children.
2009803 - Great vein and right atrial thrombosis in critically ill infants and children with cent...
16462293 - Increased reported cases of tuberculosis among children younger than 5 years of age, ma...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  129     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-12-13     Completed Date:  1996-12-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  677-9     Citation Subset:  AIM; IM    
Department of Paediatric Cardiology, University Hospital Münster, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Factor V / genetics*
Heart Diseases / complications*
Infant, Newborn
Protein C / genetics*
Retrospective Studies
Risk Factors
Thromboembolism / etiology,  genetics*
Reg. No./Substance:
0/Protein C; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone ace...
Next Document:  Changing patterns of red blood cell transfusion in very low birth weight infants.