Document Detail

Thromboembolism in pregnancy: recurrence risks, prevention and management.
MedLine Citation:
PMID:  18989130     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The purpose of this review is to summarize the epidemiology of thromboembolism in pregnancy and describe strategies to prevent and treat it. RECENT FINDINGS: The main reason for the increased risk of thrombosis in pregnancy is hypercoagulability. Other risk factors include a history of thrombosis, inherited and acquired thrombophilia, certain medical conditions, and complications of pregnancy and childbirth. SUMMARY: The hypercoagulability of pregnancy is present as early as the first trimester and so is the increased risk of thrombosis. Candidates for anticoagulation are women with a current thrombosis, a history of thrombosis, thrombophilia and a history of poor pregnancy outcome, or risk factors for postpartum thrombosis. For fetal reasons, the preferred agents for anticoagulation in pregnancy are heparins. There are no large trials of anticoagulants in pregnancy and recommendations are based on case series and the opinion of experts. Nonetheless, anticoagulants are believed to improve the outcome of pregnancy for women and their fetuses.
Andra H James
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  20     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-07     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  550-6     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Cesarean Section
Postpartum Period
Pregnancy Complications, Cardiovascular
Pregnancy Outcome
Risk Factors
Thromboembolism / complications*,  epidemiology,  prevention & control*,  therapy*
Thrombophilia / complications,  epidemiology
Treatment Outcome
Reg. No./Substance:

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