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Thromboembolism in patients with nonvalvular atrial fibrillation: Comparison between Asian and Western countries.
MedLine Citation:
PMID:  23068291     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Atrial fibrillation (AF) is one of the common cardiac arrhythmias and is responsible for increased mortality and various morbidities. The prevalence, mortality, morbidity, and treatment strategy for AF might differ between Western countries and Asian countries including Japan. AF prevalence in elderly subjects (≥80 years old) is relatively low in Japan, Korea, and Taiwan as compared with Western countries. In contrast, the prevalence in mainland China is intermediate between Japan and Western countries. CHADS(2) score and its new version, CHA(2)DS(2)-VASc score, are useful to predict subsequent thromboembolic events in Japanese AF patients. Guidelines in Western countries recommend target anticoagulation levels for prevention of thromboembolic and major hemorrhagic events at prothrombin time international normalized ratio (PT-INR) of 2-3. However, relatively lower PT-INR levels could be suitable for prevention of these events among patients with nonvalvular AF in Japan and China. New oral anticoagulants have been launched in Japan as an alternative to warfarin. The management strategy for AF patients needs to be modified based on the data obtained from Japanese patients.
Authors:
Hiroshi Inoue
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Journal of cardiology     Volume:  -     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Second Department of Internal Medicine, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama 930-0194, Japan. Electronic address: hiroshi@med.u-toyama.ac.jp.
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