Document Detail

Thromboembolism in patients with the 'lupus'-type circulating anticoagulant.
MedLine Citation:
PMID:  6367679     Owner:  NLM     Status:  MEDLINE    
Thirty-five patients with the lupus anticoagulant (LA) were followed up between 1975 and 1982. The most prevalent clinical manifestation occurring in these patients was thrombosis. Nineteen patients (54.3%) had a single or recurrent thrombotic episode. Fifteen patients (42.8%) had venous thrombosis, and arterial thrombosis manifested by stroke or transient ischemic attacks occurred in six patients. Bleeding occurred in only five patients, four of whom had severe thrombocytopenia, while no excessive bleeding was noted during 18 operative procedures. Various therapeutic regimens, including corticosteriods, nonsteroidal anti-inflammatory drugs, cytotoxic or immunosuppressive agents, had no effect on the presence of the LA in these patients. Anticoagulants were successful in the treatment and prevention of thrombotic episodes.
M Elias; A Eldor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of internal medicine     Volume:  144     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-03-27     Completed Date:  1984-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  510-5     Citation Subset:  AIM; IM    
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MeSH Terms
Anticoagulants / therapeutic use
Epoprostenol / blood
Middle Aged
Partial Thromboplastin Time
Splenomegaly / complications
Thrombin Time
Thromboembolism / complications,  drug therapy,  immunology*
Reg. No./Substance:
0/Anticoagulants; 35121-78-9/Epoprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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