Document Detail

Thromboembolism in newborns, infants and children.
MedLine Citation:
PMID:  11487037     Owner:  NLM     Status:  MEDLINE    
As in adults, acquired and inherited prothrombotic risk factors increase the risk of thrombosis in neonates, infants and children. Duplex sonography, venography, computed tomography and magnetic resonance imaging can be used to diagnose childhood thromboembolism, but venography is the recommended method to confirm vascular occlusion of the upper venous system. After suffering thrombosis, patients should be screened for factor V G1691A, prothrombin G20210A and MTHFR C677T genotypes, deficiencies of protein C, protein S, and antithrombin, elevation of lipoprotein (a) and fasting homocysteine concentrations (3 to 6 months after thrombotic onset: plasma-based assays). Data interpretation is based on age-dependent reference ranges and the identification of causative gene mutations/polymorphisms with respect to the individual ethnic background. Paediatric treatment protocols for acute thromboembolism, including thrombolytic and anticoagulant therapy, are hampered by the lack of appropriate clinical trials. Thus, recommendations from small-scale studies in paediatric patients and guidelines adapted from adult patient protocols may be helpful in the management of paediatric patients on an individual patient basis.
U Nowak-Göttl; A Kosch; N Schlegel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  86     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2002-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  464-74     Citation Subset:  IM    
Department of Paediatric Haematology/Oncology, University of Münster, Germany.
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MeSH Terms
Anticoagulants / therapeutic use
Child Welfare
Child, Preschool
Infant Welfare
Infant, Newborn
Risk Factors
Thromboembolism / blood,  diagnosis,  etiology*
Thrombophilia / blood,  epidemiology,  genetics
Reg. No./Substance:

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