| Thromboembolism and antithrombotic therapy in peripheral arterial disease. | |
| | |
MedLine Citation:
|
PMID: 2946749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Atherosclerosis complicated by thromboembolism is the main cause of obstructive arterial disease in the legs. Two studies from West Germany suggest that antiplatelet drugs may slow the progress of atherosclerosis in leg arteries and prevent occlusive thrombosis under some circumstances. The same agents may also reduce the risk of rethrombosis after successful vascular repair in the femoropopliteal region; in one trial, aspirin decreased the incidence of reocclusion after thromboendarterectomy and, in another, the combination of aspirin and dipyridamole was effective after bypass with synthetic material. Antithrombotic drugs are used in most centers after percutaneous transluminal angioplasty, but there is no definite evidence for their need. Thus, it appears that in contrast to cardiac and cerebrovascular disease, few efforts have been made to determine the true value of antithrombotic therapy in peripheral arterial disease. The management of acute thromboembolism in the legs requires a multidisciplinary approach. Depending on the type (embolic or thrombotic), length and localization of the arterial occlusion, surgical (embolectomy, thromboendarterectomy, peripheral bypass surgery) or nonsurgical (systemic fibrinolysis or local thrombolytic therapy with or without balloon angioplasty) treatment is preferred. The importance of nonsurgical therapeutic approaches may become even greater in elderly patients with a poor operative risk. This review discusses the available therapeutic modalities in acute and chronic peripheral thromboembolic arterial disease. |
| | |
Authors:
|
H Bounameaux; R Verhaeghe; M Verstraete |
Related Documents
:
|
8727509 - Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery ... 18001609 - Exertional leg pain: teasing out arterial entrapments. 2120939 - Determination of the extent of lower-extremity peripheral arterial disease with color-a... 3115579 - Renal embolization: a study of the interaction of contrast media and ethanol. 12086669 - Sensory nerves determine the pattern of arterial differentiation and blood vessel branc... 3282639 - Subclavian artery occlusion after radiotherapy for carcinoma of the breast. 8698759 - Twice sealed-rupture of a small abdominal aortic aneurysm with unusual computed tomogra... 17904809 - Rapid progression of aortic wall vegetation. 6598069 - One millimetre polytetrafluoroethylene (gore-tex) as a microvascular prosthesis: techni... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 8 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1986 Dec |
Date Detail:
|
Created Date: 1987-01-02 Completed Date: 1987-01-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 98B-103B Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Balloon Anticoagulants / therapeutic use* Arteriosclerosis / complications Fibrinolytic Agents / therapeutic use* Graft Occlusion, Vascular / prevention & control Humans Ischemia / prevention & control Leg / blood supply* Thromboembolism / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants; 0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The pathogenesis and prevention of aortocoronary vein bypass graft occlusion and restenosis after ar...
Next Document: The effect of nutritional support on T-lymphocyte subpopulations in protein calorie malnutrition.