Document Detail

Thromboembolic disease in vasculitis.
MedLine Citation:
PMID:  19077717     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To give an overview of recent clinical findings of thromboembolic disease in vasculitis and provide insight into possible explanations of the association between thrombosis and inflammation.
RECENT FINDINGS: A high incidence of venous thrombotic events has recently been described in four distinct cohorts of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), especially during periods of active disease. No factors other than the vasculitis itself have been identified that explain this high occurrence of thrombosis. Several studies have shown an increased rate of thrombosis in Behçet's disease, with a different clinical presentation from that observed in AAV. Recent laboratory findings provide exciting insights into a bidirectional feedback loop between coagulation and inflammation that may be applicable to vasculitis.
SUMMARY: Thrombosis is an important clinical manifestation of some types of vasculitis. Better understanding of the association of thrombosis with inflammation in vasculitis might lead to development of clinically useful biomarkers and new approaches to therapy. Additionally, study of the specific factors involved in thrombosis in systemic vasculitis could help explain the role of inflammation in more common settings of venous thrombotic events.
Gunnar Tomasson; Paul A Monach; Peter A Merkel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  21     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-20     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
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MeSH Terms
Autoantibodies / immunology
Behcet Syndrome / immunology
Biological Markers / analysis
Blood Coagulation Disorders / immunology*,  physiopathology*,  therapy
Diagnosis, Differential
Immunotherapy / trends
Neutrophils / immunology
Thromboembolism / immunology*,  physiopathology*,  therapy
Vasculitis / complications*,  immunology*
Grant Support
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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