Document Detail


Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management.
MedLine Citation:
PMID:  15990160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with the nephrotic syndrome are at increased risk of developing venous and arterial thromboembolism, the most common of which is renal vein thrombosis. There are several unanswered or controversial issues relating to the nephrotic syndrome and thromboembolism, which include the mechanism of thromboembolism, and optimal diagnostic and anticoagulant management strategies. This review will discuss several of these issues: the epidemiology and clinical spectrum of thromboembolic disease occurring in patients with the nephrotic syndrome; the pathophysiology of the hypercoagulable state associated with the nephrotic syndrome; the diagnosis of renal vein thrombosis in the nephrotic syndrome; and the evidence for prophylactic and therapeutic anticoagulation strategies in such patients.
Authors:
Rajni Singhal; K Scott Brimble
Publication Detail:
Type:  Journal Article; Review     Date:  2005-06-28
Journal Detail:
Title:  Thrombosis research     Volume:  118     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-24     Completed Date:  2007-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-407     Citation Subset:  IM    
Affiliation:
Department of Medicine, McMaster University, 25 Charlton Avenue East, Suite 708, Hamilton, Ontario, Canada L8N lY2.
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / therapeutic use*
Humans
Nephrotic Syndrome / complications*,  drug therapy*
Physician's Practice Patterns
Practice Guidelines as Topic*
Thromboembolism / diagnosis,  drug therapy*,  etiology*
Chemical
Reg. No./Substance:
0/Anticoagulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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