Document Detail

Thrombocytosis, coronary thrombosis and acute myocardial infarction.
MedLine Citation:
PMID:  474596     Owner:  NLM     Status:  MEDLINE    
Clinical and morphologic findings are described in a 22 year old man with prolonged thromboyctosis, and coronary and splenic arterial thrombi causing myocardial and splenic infarcts. The absence of preexistent extensive coronary atherosclerosis, the presence of thrombus in more than one epicardial artery and in multiple intramural coronary arteries, the presence of arterial thrombosis in a noncoronary artery (splenic) and the absence of another apparent cause of the arterial thromboses are evidences that the intraarterial clotting in this patient was related to the severe thrombocytosis. A reveiw of the reported cases of vascular occlusion associated with thrombocytosis indicates that thrombi have infrequently been confirmed as the mechanism of the vascular occlusion. Although the frequency of vascular thrombi in patients with thrombocytosis has not been established, it is clear that vascular thrombosis can be a consequence of thrombocytosis and, as demonstrated by the present patient, that the coronary artery may be the site of the vascular occlusion, a heretofore unconfirmed event.
R Virmani; M A Popovsky; W C Roberts
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  67     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  498-506     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Disease / etiology*,  pathology
Coronary Vessels / pathology
Myocardial Infarction / etiology*
Myocardium / pathology
Splenic Artery
Splenic Infarction / etiology,  pathology
Thrombocytosis / complications*,  diagnosis,  pathology
Thrombosis / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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