| Thrombocytosis associated with enzyme replacement therapy in Gaucher disease. | |
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MedLine Citation:
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PMID: 12187028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with an intact spleen and moderately severe symptoms of Gaucher disease in whom, after initiation of (low-dose) enzyme replacement therapy (ERT), thrombocytosis (720 x 10(9)/l) was documented. Checking the International Gaucher Registry database revealed that this patient is the only nonsplenectomized patient of more than 1,000 treated patients to experience ERT-induced thrombocytosis. Platelet counts dropped immediately after the discontinuation of ERT. |
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Authors:
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Altoon Dweck; Dorit Blickstein; Deborah Elstein; Ari Zimran |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta haematologica Volume: 108 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-08-20 Completed Date: 2002-10-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 94-6 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Enzymes / adverse effects, therapeutic use* Female Gaucher Disease / complications, drug therapy*, pathology Humans Platelet Count Spleen Thrombocytosis / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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